MedAlliance gathers economic development organisations (ANIMA, leader of the programme),  CCIs (ASCAME, EUROCHAMBRES), and business federations (BUSINESSMED). The members of these networks, as well as their special partners (UNIDO, GTZ, EPA Euroméditerranée, World Bank, etc.), gather a thousand of economic actors  - mobilised through pilot initiatives centered on key Mediterranean promising niches. Each year, a hundred operations associate the 27 countries of the European Union and 9 Mediterranean partner countries: Algeria, Egypt, Israel, Jordan, Lebanon, Morocco, Palestinian Authority, Syria and Tunisia.

They are divided along the following lines: Networking (BtoB events, Business Representative Organisations matchmaking, conferences); Assistance (support missions and short/long term staff exchanges); Training (workshops); Documentation (guide books, economic intelligence, reports). Other major issues addressed by the program relate to young and women entrepreneurs, Diasporas, micro-enterprises, franchising and leasing, public-private partnerships and access to financing.